Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates

Summary: Transactive response DNA-binding protein of 43 kDa (TDP-43) is a highly conserved, ubiquitously expressed nucleic acid-binding protein that regulates DNA/RNA metabolism. Genetics and neuropathology studies have linked TDP-43 to several neuromuscular and neurological disorders including amyo...

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Principais autores:	Baggio A. Evangelista, Shannon R. Cahalan, Joey V. Ragusa, Angie Mordant, Julie C. Necarsulmer, Robert J. Perna, Tejazaditya Ajit, Kristen White, Natalie K. Barker, Xu Tian, Sarah Cohen, Rick Meeker, Laura E. Herring, Todd J. Cohen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-05-01
coleção:	iScience
Assuntos:	Biological sciences Biochemistry Molecular biology Proteomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004223007228
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