Pichia pastoris-Expressed Bivalent Virus-Like Particulate Vaccine Induces Domain III-Focused Bivalent Neutralizing Antibodies without Antibody-Dependent Enhancement in Vivo

Dengue, a significant public health problem in several countries around the world, is caused by four different serotypes of mosquito-borne dengue viruses (DENV-1, -2, -3, and -4). Antibodies to any one DENV serotype which can protect against homotypic re-infection, do not offer heterotypic cross-pro...

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Detalhes bibliográficos

Principais autores:	Rahul Shukla, Ravi K. Rajpoot, Upasana Arora, Ankur Poddar, Sathyamangalam Swaminathan, Navin Khanna
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-01-01
coleção:	Frontiers in Microbiology
Assuntos:	dengue virus recombinant tetravalent vaccine virus-like particle envelope protein antibodydependent enhancement AG129 model
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fmicb.2017.02644/full
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