Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor

ABSTRACT Expediting drug discovery to fight antibacterial resistance requires holistic approaches at system levels. In this study, we focused on the human-adapted pathogen Haemophilus influenzae, and by constructing a high-quality genome-scale metabolic model, we rationally identified new metabolic...

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Autori principali:	Nahikari López-López, David San León, Sonia de Castro, Roberto Díez-Martínez, Manuel Iglesias-Bexiga, María José Camarasa, Margarita Menéndez, Juan Nogales, Junkal Garmendia
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2022-04-01
Serie:	mSystems
Soggetti:	Haemophilus influenzae airway infection genome-scale metabolic model gene essentiality screening fatty acid synthesis FabH inhibition
Accesso online:	https://journals.asm.org/doi/10.1128/msystems.01459-21
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