Synthetic oleanane triterpenoids suppress MYB oncogene activity and sensitize T-cell acute lymphoblastic leukemia cells to chemotherapy

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with poor prognosis. The MYB oncogene encodes a master transcription factor that is activated in the majority of human T-ALLs. In the present study, we have performed a large-scale screening with small-molecule drugs...

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Principais autores:	Paloma Tejera Nevado, Tajana Tešan Tomić, Ali Atefyekta, André Fehr, Göran Stenman, Mattias K. Andersson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-04-01
coleção:	Frontiers in Oncology
Assuntos:	MYB acute lymphoblastic leukemia oleanane triterpenoid bardoxolone methyl omaveloxolone
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1126354/full
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