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Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection

Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes following release and maturation. However, it is uncl...

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Hoofdauteurs: Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications Ltd 2024-08-01
Reeks:eLife
Onderwerpen:
viroporin
rimantadine
Zika
Flavivirus
ion channel
virus entry
Online toegang:https://elifesciences.org/articles/68404
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