EZH2 Inhibition Restores Tumor Suppressor SFRP1 Activity by Reprogramming Extrachromosomal Circular DNA Dynamics in Ovarian Cancer

Extrachromosomal circular DNA (eccDNA) has emerged as a pivotal contributor to cancer progression, facilitating oncogene amplification, dysregulated gene expression, and tumor heterogeneity. Despite its significance in cancer, the interplay between eccDNA and key epigenetic regulators such as EZH2 r...

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Principais autores:	Tao Han, Qingya Yan, Yaqi Zhang, Yu Gan, Kaifan Li, Liping Guan, Changqin Jing, Ciqing Yang, Pengfei Li, Bo Gao, Xiang Zhou, Qian Hao
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2026-02-01
Serija:	Biology
Teme:	eccDNA single-cell spatial transcriptomics Tazemetostat epigenetic regulatory SFRP1
Online dostop:	https://www.mdpi.com/2079-7737/15/4/340
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