Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites.

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca²⁺ from intracellular stores to activate stage-specific Ca²⁺-dependent protein kinases. Using the motility of Plasmodium berghei ookinetes as a signalling paradigm, we show that the cyclic guanosine monophosphate (...

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Auteurs principaux:	Mathieu Brochet, Mark O Collins, Terry K Smith, Eloise Thompson, Sarah Sebastian, Katrin Volkmann, Frank Schwach, Lia Chappell, Ana Rita Gomes, Matthew Berriman, Julian C Rayner, David A Baker, Jyoti Choudhary, Oliver Billker
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2014-03-01
Collection:	PLoS Biology
Accès en ligne:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001806&type=printable
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