Organotypic whole hemisphere brain slice models to study the effects of donor age and oxygen-glucose-deprivation on the extracellular properties of cortical and striatal tissue

Abstract Background The brain extracellular environment is involved in many critical processes associated with neurodevelopment, neural function, and repair following injury. Organization of the extracellular matrix and properties of the extracellular space vary throughout development and across dif...

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Detalhes bibliográficos

Principais autores:	Michael McKenna, Jeremy R. Filteau, Brendan Butler, Kenneth Sluis, Michael Chungyoun, Nels Schimek, Elizabeth Nance
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-06-01
coleção:	Journal of Biological Engineering
Assuntos:	Brain slices Organotypic Extracellular Brain microenvironment Nanoparticle diffusion Particle tracking
Acesso em linha:	https://doi.org/10.1186/s13036-022-00293-w
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