A complex of α6 integrin and E‐cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin‐like 6

Abstract Homing of colorectal cancer (CRC) cells to the liver is a non‐random process driven by a crosstalk between tumour cells and components of the host tissue. Here we report the isolation of a liver metastasis‐specific peptide ligand (CGIYRLRSC) that binds a complex of E‐cadherin and α6 integri...

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Detalles Bibliográficos

Principais autores:	Serena Marchiò, Marco Soster, Sabrina Cardaci, Andrea Muratore, Alice Bartolini, Vanessa Barone, Dario Ribero, Maria Monti, Paola Bovino, Jessica Sun, Raffaella Giavazzi, Sofia Asioli, Paola Cassoni, Lorenzo Capussotti, Piero Pucci, Antonella Bugatti, Marco Rusnati, Renata Pasqualini, Wadih Arap, Federico Bussolino
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer Nature 2012-10-01
Series:	EMBO Molecular Medicine
Assuntos:	angiopoietin‐like 6 E‐cadherin metastatic colorectal cancer microenvironment α6 integrin
Acceso en liña:	https://doi.org/10.1002/emmm.201101164
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