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Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections

A major goal of biological imaging is localization of biomolecules inside a cell. Fluorescence microscopy can localize biomolecules inside whole cells and tissues, but its ability to count biomolecules and accuracy of the spatial coordinates is limited by the wavelength of visible light. Cryo-electr...

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Bibliografiske detaljer
Principais autores: Johannes Elferich, Giulia Schiroli, David T Scadden, Nikolaus Grigorieff
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2022-11-01
Serier:eLife
Fag:
Online adgang:https://elifesciences.org/articles/80980
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