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Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study

Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome. Coumarins are phenolic molecules found in several...

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Autori principali: Karoline Sanches, Raphael Vinicius Rodrigues Dias, Paulo Henrique da Silva, Marcelo Andrés Fossey, Ícaro Putinhon Caruso, Fátima Pereira de Souza, Leandro Cristante de Oliveira, Fernando Alves de Melo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019-11-01
Serie:Heliyon
Soggetti:
Biochemistry
Molecular biology
Biophysics
Biophysical chemistry
Spectroscopy
Biomolecules
Accesso online:http://www.sciencedirect.com/science/article/pii/S2405844019365284
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