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The fluoroquinoline compound exerts anti-erythroleukemic effects by dual-targeting GLUT1 and the PI3K/AKT signaling pathway

Abstract Erythroleukemia is a rare hematological malignancy in clinical practice, and currently, there are no effective treatment options other than stem cell transplantation. The study found that the fluoroquinoline compound FKL-137 can significantly inhibit the proliferation of erythroleukemia cel...

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Main Authors: Sha Cheng, Weijia Zhao, Jia Yu, Xueling Meng, Bixue Xu, Ningning Zan, Baofei Sun, Heng Luo
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-03-01
Series:Scientific Reports
Subjects:
Fluoroquinoline
Erythroleukemia
GLUT1
PI3K/AKT
Glucose metabolism
Glycolysis
Online Access:https://doi.org/10.1038/s41598-026-45597-9
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