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Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

Continued methodological advances have enabled numerous statistical approaches for the analysis of summary statistics from genome-wide association studies. Genetic correlation analysis within specific regions enables a new strategy for identifying pleiotropy. Genomic regions with significant ‘local’...

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Principais autores: Thomas P Spargo, Lachlan Gilchrist, Guy P Hunt, Richard JB Dobson, Petroula Proitsi, Ammar Al-Chalabi, Oliver Pain, Alfredo Iacoangeli
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2024-12-01
coleção:eLife
Assuntos:
fine-mapping
neurodegenerative diseases
colocalisation
local genetic correlation
Acesso em linha:https://elifesciences.org/articles/88768
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