Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis.

<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that specifically affects motor neurons and leads to a progressive and ultimately fatal loss of function, resulting in death typically within 3 to 5 years of diagnosis. The disease starts with a focal centre of wea...

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Autors principals:	Ruth Chia, M Howard Tattum, Samantha Jones, John Collinge, Elizabeth M C Fisher, Graham S Jackson
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2010-05-01
Col·lecció:	PLoS ONE
Accés en línia:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010627&type=printable
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