Novel Sophoridine Derivatives Bearing Phosphoramide Mustard Moiety Exhibit Potent Antitumor Activities In Vitro and In Vivo

Novel mustard functionalized sophoridine derivatives were synthesized and evaluated for their cytotoxicity against of a panel of various cancer cell lines. They were shown to be more sensitive to S180 and H22 tumor cells with IC50 values ranging from 1.01–3.65 μM, and distinctly were more c...

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Hlavní autoři:	Dongdong Li, Linlin Dai, Xiumei Zhao, Shuang Zhi, Hongsheng Shen, Zibo Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2018-08-01
Edice:	Molecules
Témata:	mustard functionalized sophoridine derivatives antitumor activity apoptosis
On-line přístup:	http://www.mdpi.com/1420-3049/23/8/1960
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