Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L × GSK3β mice by delaying brainstem tauopathy

Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in autonomic brainstem circuits that control breathing (Dutschmann et al., 2010). In individual mice, the clinical phenotype evolves progressively and rapidly (...

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Bibliografski detalji

Glavni autori:	Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Hervé Maurin, Fred Van Leuven
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2014-07-01
Serija:	Neurobiology of Disease
Teme:	GSK3 Protein Tau Tauopathy Brainstem Survival
Online pristup:	http://www.sciencedirect.com/science/article/pii/S0969996114000771
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