Green Approach to Enhance Dissolution of Gliclazide: Thermoresponsive Solid Dispersion Based on Poloxamer 188/Propylene Glycol/Labrasol Ternary System

<b>Background/Objectives:</b> Gliclazide’s limited water solubility restricts its absorption across the gastrointestinal tract and compromises its therapeutic performance. This study developed a thermoresponsive solid dispersion based on the inverted thermoresponsive behavior of poloxamer 188 in pro...

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Principais autores:	Abdelrahman Y. Sherif, Mohamed A. Ibrahim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-06-01
coleção:	Pharmaceutics
Assuntos:	thermoresponsive solid dispersion poloxamer 188 gliclazide labrasol I-optimal mixture design
Acesso em linha:	https://www.mdpi.com/1999-4923/18/6/702
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