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Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation

Background: Disruption of DNA methylation (DNAm) is one of the key signatures of cancer, however, detailed mechanisms that alter the DNA methylome in cancer remain to be elucidated. Methods: Here we present a novel integrative analysis framework, called MeLncTRN (Methylation mediated LncRNA Transcri...

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Principais autores: Zhen Yang, Feng Xu, Haizhou Wang, Andrew E Teschendorff, Feng Xie, Yungang He
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-06-01
Serier:EBioMedicine
Fag:
DNA methylation
LncRNA
Transcriptional regulation
Omics-data integration
Regulatory network
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396421001924
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