High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach
IntroductionThe cytochrome P450 enzyme 3A4 (CYP3A4) mediates numerous drug-drug interactions (DDIs) by inducing the metabolism of co-administered drugs, which can result in reduced therapeutic efficacy or increased toxicity. This study developed and validated a Physiologically Based Pharmacokinetic...
Furkejuvvon:
| Váldodahkkit: | , , , , , |
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| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
Frontiers Media S.A.
2025-02-01
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| Ráidu: | Frontiers in Pharmacology |
| Fáttát: | |
| Liŋkkat: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1521068/full |
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