Beta amyloid differently modulate nicotinic and muscarinic receptor subtypes which regulate in vitro and in vivo the release of glycine in the rat hippocampus

Using both in vitro (hippocampal synaptosomes in superfusion) and in vivo (microdialysis) approaches we investigated whether and to what extent β amyloid peptide 1-40 (Aβ 1-40) interferes with the cholinergic modulation of the release of glycine (GLY) in the rat hippocampus. The nicotine-evoked over...

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Detalhes bibliográficos

Principais autores:	Stefania eZappettini, Massimo eGrilli, Guendalina eOlivero, Elisa eMura, Stefania ePreda, Stefano eGovoni, Alessia eSalamone, Mario eMarchi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2012-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	Microdialysis nicotinic receptors muscarinic receptors glycine release β amyloid
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00146/full
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