Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease

Abstract Prime editing offers versatile genome modifications with therapeutic potential; yet its use to modulate neural circuitry remains underexplored. Here, we used adeno-associated viral vectors to deliver prime editors into the mouse brain and introduced the naturally occurring Adrb1 A187V varia...

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Detalhes bibliográficos

Principais autores:	Desirée Böck, Lisa Tidecks, Maria Wilhelm, Waleed ElGrawani, Sian Duss, Chiara Trevisan, Dalila Vena, Anna Maria Reuss, Lucas Kissling, Matteo Ranucci, Mattia Privitera, Lisa K. Polzer, Athena E. Economides, Eleonora I. Ioannidi, Raquel Mendes, Yanik Weber, Justine Leonardi, Jonas Mumenthaler, Elina Villiger, Romain Goutagny, Chantal Mathis, Lukas Schmidheini, Tanja Rothgangl, Sharan Janjuha, Tommaso Patriarchi, Johannes Bohacek, Yaroslav Sych, Adriano Aguzzi, Jochen Winterer, Konstantinos Kompotis, Gerald Schwank
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-12-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-65964-w
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