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Direct and Indirect Effect of Guselkumab on Anxiety, Depression, and Quality of Life in Patients with Moderate-to-Severe Plaque Psoriasis: A Mediation Analysis

Abstract Introduction Treating plaque psoriasis (PsO) with guselkumab (GUS) promotes skin clearance and is associated with improvements in health-related quality of life (HRQoL), anxiety, and depression. It is unclear whether improvements in patient-reported outcomes are due to resolution of skin sy...

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Main Authors: April W. Armstrong, Peter Foley, Yan Liu, Megan Miller, Rachel E. Teneralli, Anthony Bewley, Kenneth B. Gordon, Kim A. Papp, Chenglong Han
Format: Artigo
Language:Inglês
Published: Adis, Springer Healthcare 2024-08-01
Series:Dermatology and Therapy
Subjects:
Anxiety
Depression
Guselkumab
Health-related quality of life
Mediation analysis
Psoriasis
Online Access:https://doi.org/10.1007/s13555-024-01250-9
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