NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia

Ataxia–telangiectasia (A–T) is a rare, autosomal recessive, multisystem disorder caused by mutations in the Ataxia–Telangiectasia Mutated (ATM) gene and is characterized by a devastating and progressive neurological pathology. The cellular and molecular changes driving the neurological abnormalities...

Descripció completa

Dades bibliogràfiques

Autors principals:	Giuliano G. Stirparo, Xiao Xu, Toni Thompson, Keith Page, Jenna R. M. Harvey, David Cadwalladr, Jason Lawrence, Russell J. Burley, Joel Juvvanapudi, Megan Roberts, Daniel F. Barker, Victoria Mulligan, Chloe Sherlock, Marina Lizio, Louisa Christie, Mani Mudaliar, Steven Sheardown, Brad Margus, Craig Thompson, Louise Dickson, Nicola L. Brice, Mark B. Carlton, Justin A. C. Powell, Lee A. Dawson
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-09-01
Col·lecció:	Frontiers in Neuroscience
Matèries:	ataxia telangiectasia NETSseq neurodegeneration inflammation aging ATR pathway
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1636787/full
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!