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Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell Surface

A major consequence of insulin binding its receptor on fat and muscle cells is the stimulation of glucose transport into these tissues. This is achieved through an increase in the exocytic trafficking rate of the facilitative glucose transporter GLUT4 from intracellular stores to the cell surface. D...

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Principais autores: Dimitrios Kioumourtzoglou, Hannah L. Black, Mohammed Al Tobi, Rachel Livingstone, John R. Petrie, James G. Boyle, Gwyn W. Gould, Nia J. Bryant
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-12-01
Serier:Biomolecules
Fag:
membrane traffic
Syntaxin
SNARE complex: insulin action
GLUT4
Online adgang:https://www.mdpi.com/2218-273X/13/12/1738
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