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Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory

Neurotrophin brain-derived neurotrophic factor (BDNF) and neurotransmitter serotonin (5-HT) regulate each other and have been implicated in several neuronal mechanisms, including neuroplasticity. We have investigated the effects of BDNF on serotonergic neurons by deleting BDNF receptor TrkB from ser...

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Principais autores: Madhusmita P. Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castrén
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-04-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
serotonin
TrkB
BDNF
neuronal plasticity
neurotrophic factor
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnmol.2021.616178/full
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