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Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population

Plasma total homocysteine (tHCY) is a known risk factor of a wide range of complex diseases. No genome scans for tHCY have been conducted in East Asian populations. Here, we conducted an exome-wide association study (ExWAS) for tHCY in 5,175 individuals of Chinese Han origin, followed by a replicati...

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Principais autores: Tianzi Liu, Mohetaboer Momin, Huiyue Zhou, Qiwen Zheng, Fangfang Fan, Jia Jia, Mengyuan Liu, Minghui Bao, Jianping Li, Yong Huo, Jialin Liu, Yaning Zhang, Xuemei Mao, Xiao Han, Zhiyuan Hu, Changqing Zeng, Fan Liu, Yan Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-10-01
Serier:Frontiers in Genetics
Fag:
homocysteine
hyperhomocysteinemia
MTHFR C677T
MTHFR C136T
coding variants
population heterogeneity
Online adgang:https://www.frontiersin.org/articles/10.3389/fgene.2021.717621/full
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