Reassessing the Conduct of Patch Clamp Cardiac Ion Channel Assays to Improve Nonclinical Data Translation to Clinical ECG Changes and Proarrythmia Risk

ABSTRACT The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative proposes integrating multi‐cardiac ion channel pharmacology to improve the prediction of drug‐induced Torsade de Pointes (TdP) risk. However, several studies under CiPA have demonstrated misalignment between nonclinical and cl...

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Xehetasun bibliografikoak

Egile Nagusiak:	Claudia Alvarez Baron, Jun Zhao, Donglin Guo, Sabyasachy Mistry, Ryan De Palma, Omnia A. Ismaiel, Wendy W. Wu
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Wiley 2025-12-01
Saila:	Clinical and Translational Science
Gaiak:	cardiac safety CaV1.2 CiPA hERG assay NaV1.5 QTC prolongation
Sarrera elektronikoa:	https://doi.org/10.1111/cts.70451
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