Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes. Here we investigate enhancer cooperation during transdifferentiation of human leukemia B-cells to macrophages. Putative enhancers are established by bindi...

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Detalles Bibliográficos

Autores principales:	Jinmi Choi, Kseniia Lysakovskaia, Gregoire Stik, Carina Demel, Johannes Söding, Tian V Tian, Thomas Graf, Patrick Cramer
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2021-03-01
Colección:	eLife
Materias:	transdifferentiation transcriptional regulation enhancer cooperation c/ebpa
Acceso en línea:	https://elifesciences.org/articles/65381
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