Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Abstract EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol. Here, we d...

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Bibliographic Details

Main Authors:	Candice Sartre, François Peurois, Marie Ley, Marie-Hélène Kryszke, Wenhua Zhang, Delphine Courilleau, Rodolphe Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianferani, Yann Ferrandez, Jacqueline Cherfils
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2023-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-39894-4
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