Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1SS4+) and neurexin-3 (Nrxn3SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1SS4+ and Nrxn3SS4+ act by binding to secreted cerebellin-2 (Cbln2) that in turn activates pos...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jinye Dai, Kif Liakath-Ali, Samantha Rose Golf, Thomas C Südhof
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	eLife Sciences Publications Ltd 2022-10-01
Sarja:	eLife
Aiheet:	synaptic transmission cerebellins hippocampus neurexin signaling specificity prefrontal cortex cerebellum
Linkit:	https://elifesciences.org/articles/78649
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