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Protein language model identifies disordered, conserved motifs implicated in phase separation

Intrinsically disordered regions (IDRs) play a critical role in phase separation and are essential for the formation of membraneless organelles (MLOs). Mutations within IDRs can disrupt their multivalent interaction networks, altering phase behavior and contributing to various diseases. Therefore, e...

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Autori principali: Yumeng Zhang, Jared Zheng, Bin Zhang
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2025-10-01
Serie:eLife
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Accesso online:https://elifesciences.org/articles/105309
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