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Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo.

Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. Although HR is mostly error free, inherent or environmental conditions that either suppress or induce HR cause genomic instability. Despite its importance in carcinogenesis, due to limitati...

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Principais autores: Michelle R Sukup-Jackson, Orsolya Kiraly, Jennifer E Kay, Li Na, Elizabeth A Rowland, Kelly E Winther, Danielle N Chow, Takafumi Kimoto, Tetsuya Matsuguchi, Vidya S Jonnalagadda, Vilena I Maklakova, Vijay R Singh, Dushan N Wadduwage, Jagath Rajapakse, Peter T C So, Lara S Collier, Bevin P Engelward
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-06-01
Serier:PLoS Genetics
Online adgang:http://europepmc.org/articles/PMC4046920?pdf=render
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