Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

Poly (ADP-ribose) (PAR) is a negatively charged polymer that is biosynthesized by Poly (ADP-ribose) Polymerase-1 (PARP-1) and regulates various cellular processes. Alpha-synuclein (αSyn) is an intrinsically disordered protein (IDP) that has been directly implicated with driving the onset and progres...

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Bibliografiske detaljer

Principais autores:	Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider, Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski, Robert H. Mach
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-06-01
Serier:	Frontiers in Aging Neuroscience
Fag:	poly (ADP-ribose) PARP-1 alpha-synclein Parkinson’s disease (PD) neurodegeneration
Online adgang:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.704041/full
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