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FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells

Abstract Background The FACT complex is a conserved histone chaperone with critical roles in transcription and histone deposition. FACT is essential in pluripotent and cancer cells, but otherwise dispensable for most mammalian cell types. FACT deletion or inhibition can block induction of pluripoten...

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Principais autores: David C. Klein, Santana M. Lardo, Kurtis N. McCannell, Sarah J. Hainer
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-08-01
Serier:BMC Biology
Fag:
FACT
Chromatin
Histone chaperone
Transcription
Embryonic stem cells
Pluripotency
Online adgang:https://doi.org/10.1186/s12915-023-01669-0
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