Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo

The clinical potential of PARP-1 inhibitors has been recognized >10 years ago, prompting intensive research on their pharmacological application in several branches of medicine, particularly in oncology. However, natural or acquired resistance of tumors to known PARP-1 inhibitors poses a serious pro...

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Auteurs principaux:	Colin Thomas, Yingbiao Ji, Niraj Lodhi, Elena Kotova, Aaron Dan Pinnola, Konstantin Golovine, Peter Makhov, Kate Pechenkina, Vladimir Kolenko, Alexei V. Tulin
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2016-11-01
Collection:	EBioMedicine
Sujets:	PARP-1 PARP-1 inhibitors Histone-dependent PARP-1 regulation Poly(ADP-ribose) Cancer cells
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S235239641630456X
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