The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies

Immunoglobulin A nephropathy (IgAN), characterized by mesangial deposition of galactose-deficient-IgA1 (Gd-IgA1), is the most common biopsy-proven primary glomerulonephritis worldwide. Recently, an improved understanding of its underlying pathogenesis and the substantial risk of progression to kidne...

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Hlavní autoři:	Chee Kay Cheung, Jonathan Barratt, Adrian Liew, Hong Zhang, Vladimir Tesar, Richard Lafayette
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-02-01
Edice:	Frontiers in Nephrology
Témata:	B-cell activating factor BAFF a proliferation-inducing ligand APRIL IgA nephropathy dual inhibition atacicept
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fneph.2023.1346769/full
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