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Dose Dependent Biological Effects of Idarubicin in HL-60 Cells: Alterations of the Cell-Cycle and Apoptosis

TP-53 deficient cells of human leukaemia HL-60 die by massive apoptosis after treatment by high (50-100 nmol/l) doses of DNA damaging agent Idarubicin, regardless of the cell-cycle phase, in which they are affected. In contrary, after relatively low dose 10 nmol/l the cells die after cell-cycle arre...

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Principais autores: Martina Mareková, Jiřina Vávrová, Doris Vokurková
Format: Artigo
Sprog:Inglês
Udgivet: Karolinum Press 2000-01-01
Serier:Acta Medica
Fag:
HL-60
Idarubicin
Apoptosis
G2 cell-cycle arrest
Online adgang:https://actamedica.lfhk.cuni.cz/43/2/0069/
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