Robust bioprocess design and evaluation of commercial media for the serial expansion of human induced pluripotent stem cell aggregate cultures in vertical-wheel bioreactors

Abstract Background While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of PSCs require large cell quantities to be generate...

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Bibliografski detalji

Glavni autori:	Breanna S. Borys, Tiffany Dang, Hannah Worden, Leila Larijani, Jessica M. Corpuz, Brett D. Abraham, Emilie J. Gysel, Julia Malinovska, Roman Krawetz, Tamas Revay, Bob Argiropoulos, Derrick E. Rancourt, Michael S. Kallos, Sunghoon Jung
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-07-01
Serija:	Stem Cell Research & Therapy
Teme:	Stem cell bioprocessing Induced pluripotent stem cell Vertical-wheel bioreactor Serial passage Biomanufacturing Media
Online pristup:	https://doi.org/10.1186/s13287-024-03819-9
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