Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent

Four Janus kinases (JAKs) (JAK1, JAK2, JAK3, TYK2) and seven signal transducers and activators of transcription (STATs) (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6) mediate the signal transduction of more than 50 cytokines and growth factors in many different cell types. Located intracellular...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Alessia Alunno, Ivan Padjen, Antonis Fanouriakis, Dimitrios T. Boumpas
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	MDPI AG 2019-08-01
श्रृंखला:	Cells
विषय:	systemic lupus erythematosus Janus kinase protein tyrosine kinases STAT baricitinib
ऑनलाइन पहुंच:	https://www.mdpi.com/2073-4409/8/8/898
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