Endocytosis of the Saccharomyces cerevisiae Jen1 monocarboxylate-proton symporter under mildly alkaline conditions: a mechanism to prevent metabolite loss?

Abstract Background The Saccharomyces cerevisiae Jen1 transporter mediates electroneutral proton symport of lactate and pyruvate. In lactate-grown batch cultures, growth-coupled medium alkalinization was previously shown to coincide with endocytosis of Jen1. Results To investigate the physiological...

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Autors principals:	Cláudia Barata-Antunes, Marieke Warmerdam, Erik de Hulster, Inês P. Ribeiro, Clara Cardoso, Beatriz Leite, Margarida Casal, Hernâni Gerós, Jack Pronk, Joaquín Ariño, Robert Mans, Sandra Paiva
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Microbial Cell Factories
Matèries:	Transporters Carboxylic acids Endocytosis Alkali stress Lactate, pH, continuous cultivation.
Accés en línia:	https://doi.org/10.1186/s12934-026-02955-6
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