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Insights into GLP-1 and insulin secretion mechanisms in pasireotide-induced hyperglycemia highlight effectiveness of Gs-targeting diabetes treatment

Abstract Pasireotide frequently causes severe hyperglycemia; however, its detailed mechanism remains unknown. There are no published guidelines regarding the optimal management of pasireotide-induced hyperglycemia based on its pathophysiology. Herein, we successfully switched a patient with acromega...

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Principais autores: Junichiro SATO, Katsunori MANAKA, Hirofumi HORIKOSHI, Maho TAGUCHI, Kazuki HARADA, Takashi TSUBOI, Masaomi NANGAKU, Taroh IIRI, Noriko MAKITA
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-03-01
Serier:Scientific Reports
Fag:
GLP-1
GLP-1 analog
GPCRs
Insulin
L-cells
Pasireotide
Online adgang:https://doi.org/10.1038/s41598-025-90896-2
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