Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation

IntroductionIntestinal dysbiosis, characterized by reduced diversity and enrichment of pro-inflammatory taxa, is implicated in the pathogenesis of polycystic ovary syndrome (PCOS). Ramulus mori (Sangzhi) alkaloids (SZ-A), approved in China for type 2 diabetes with broad metabolic effects, remain unt...

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Hlavní autoři:	Yanping Wang, Xianmei Jiang, Shuyi Wu, Qiaohui Wang, Dan Zuo, Biao Huang, Li Jian, Yu Yang, Yong Cai, Xingjian Wen, Ling Yao, Shan Geng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-01-01
Edice:	Frontiers in Pharmacology
Témata:	Ramulus mori (Sangzhi) alkaloids PCOS intestinal oxidative damage inflammatorystatus intestinal microbiome and metabolites fenoldopam
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1701694/full
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