Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice.

Enterovirus A71 (EV-A71) causes hand, foot and mouth disease epidemics with neurological complications and fatalities. However, the neuropathogenesis of EV-A71 remains poorly understood. In mice, adaptation and virulence determinants have been mapped to mutations at VP2-149, VP1-145 and VP1-244. We...

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Detalhes bibliográficos

Principais autores:	Han Kang Tee, Chee Wah Tan, Thinesshwary Yogarajah, Michelle Hui Pheng Lee, Hann Juang Chai, Nur Aziah Hanapi, Siti R Yusof, Kien Chai Ong, Vannajan Sanghiran Lee, I-Ching Sam, Yoke Fun Chan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2019-11-01
coleção:	PLoS Pathogens
Acesso em linha:	https://doi.org/10.1371/journal.ppat.1007863
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