In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes.

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Mahmoud ElHefnawi, TaeKyu Kim, Mona A Kamar, Saehong Min, Nafisa M Hassan, Eman El-Ahwany, Heeyoung Kim, Suher Zada, Marwa Amer, Marc P Windisch
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2016-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://doi.org/10.1371/journal.pone.0159211
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