Investigating the pathogenesis of urolithiasis through gut microbiome, plasma metabolome and inflammatory proteome: a mediation Mendelian randomization study

Abstract Background Urolithiasis is a multifactorial systemic metabolic disease influenced by genetic, environmental, and dietary factors. Although previous observational studies have established strong links between the gut microbiome, plasma metabolome, inflammatory proteome, and urolithiasis, may...

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Hauptverfasser:	Guanwei Wu, Weiyu Zhu, Guoxiang Li, Yuexian Xu, Yingqing Liu, Lingsong Tao, Zongyao Hao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Clinical Epigenetics
Schlagworte:	Gut microbiota Plasma metabolites Inflammatory proteins Urolithiasis Gut-kidney axis Mendelian randomization
Online-Zugang:	https://doi.org/10.1186/s13148-025-02014-8
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