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The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation

Junin virus (JUNV) is a member of the Arenaviridae family of viruses and is the pathogen responsible for causing Argentine hemorrhagic fever, a potentially lethal disease endemic to Argentina. A live attenuated vaccine for human use, called Candid#1, is approved only in Argentina. Candid#1 vaccine s...

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Main Authors: John Tyler Manning, Junki Maruyama, Timothy Wanninger, Rachel A. Reyna, Heather L. Stevenson, Bi-Hung Peng, Emily K. Mantlo, Cheng Huang, Slobodan Paessler
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
Candid #1 vaccine
Junin virus
neurovirulence
vaccine safety
arenavirus diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172792/full
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