Nature-Inspired 1-Phenylpyrrolo[2,1-<i>a</i>]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance

Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-<i>a</i>]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may reverse multidrug resistance (MDR) mediate...

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Hauptverfasser:	Alisa A. Nevskaya, Rosa Purgatorio, Tatiana N. Borisova, Alexey V. Varlamov, Lada V. Anikina, Arina Yu. Obydennik, Elena Yu. Nevskaya, Mauro Niso, Nicola A. Colabufo, Antonio Carrieri, Marco Catto, Modesto de Candia, Leonid G. Voskressensky, Cosimo D. Altomare
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-04-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	pyrrolo[2,1-<i>a</i>]isoquinolines Mannich bases cytotoxicity P-glycoprotein inhibition multidrug resistance reversal
Online-Zugang:	https://www.mdpi.com/1424-8247/17/4/539
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