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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer

Abstract Background Lack of Schlafen family member 11 (SLFN11) expression has been recently identified as a dominant genomic determinant of response to DNA damaging agents in numerous cancer types. Thus, several strategies aimed at increasing SLFN11 are explored to restore chemosensitivity of refrac...

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Tallennettuna:
Päätekijät: Christophe Michel Raynaud, Eiman I. Ahmed, Ayesha Jabeen, Apryl Sanchez, Shimaa Sherif, Tatiana C. Carneiro-Lobo, Amany Awad, Dina Awartani, Adviti Naik, Remy Thomas, Julie Decock, Gabriele Zoppoli, Davide Bedongnetti, Wouter R. L. Hendrickx
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2023-11-01
Sarja:Cancer Cell International
Aiheet:
SLFN11
Breast cancer
Chemosensitivity
UNISAM
KRAB
Cisplatin
Linkit:https://doi.org/10.1186/s12935-023-03144-w
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