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Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum levels of Orm1 were observed in patients afte...

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Principais autores: Xian-Yang Qin, Mitsuko Hara, Erik Arner, Yoshikuni Kawaguchi, Ikuyo Inoue, Hideki Tatsukawa, Yutaka Furutani, Keisuke Nagatsuma, Tomokazu Matsuura, Feifei Wei, Jun Kikuchi, Hideko Sone, Carsten Daub, Hideya Kawaji, Timo Lassmann, Masayoshi Itoh, Harukazu Suzuki, Piero Carninci, Yoshihide Hayashizaki, Norihiro Kokudo, Alistair R.R. Forrest, Soichi Kojima
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-10-01
coleção:EBioMedicine
Assuntos:
Orosomucoid-1
Hepatocyte proliferation
Lipocalin
Cell cycle
Bioinformatics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396417303614
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