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Comparing immunotherapy re-challenge plus chemoradiotherapy versus chemoradiotherapy alone in metastatic esophageal squamous cell carcinoma after first-line immunotherapy failure

Abstract Background Immunotherapy (IO) re-challenge for cancer patients has sparked widespread discussion and attention in recent years. The optimal second-line treatment strategies for patients with metastatic esophageal squamous cell carcinoma (ESCC) after first-line IO failure remains to be furth...

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Main Authors: Jian Song, Jie Shu, Wensi Zhao
Format: Artigo
Language:Inglês
Published: Springer 2026-05-01
Series:Discover Oncology
Subjects:
Esophageal squamous cell carcinoma
Immunotherapy
Re-challenge
Chemoradiotherapy
Second-line therapy
Online Access:https://doi.org/10.1007/s12672-026-05149-z
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